Classics in Total Synthesis. By K.C. Nicolaou and E. J. Sorensen. Article (PDF Available) in Molecules 3(2) · February with 2, Reads. This book is essential for any synthetic organic chemist.[ ]. K. C. NICOLAOU, E. J. SORENSEN. CLASSICS IN. TOTAL. Page 2. Classics in Total Synthesis K. C. Nicolaou and. – E. J. Sorensen. VCH.

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Special emphasis is placed on the skillful use of graphics and schemes: Nicolaou has earned three prestigious international honors recently, including the Nemitsas Prize in Chemistry.

The layout of this book has only been slightly changed compared with previous volumes. It is amazing, as snthesis the 50’s, how projects like the synthesis of penicillin were advanced.

Such explanations, and possibly also descriptions of unsuccessful attempted routes, could give the reader an even more detailed insight into problems of reactivity or selectivity of a specific reagent or substrate. Read the press announcement: Site Search any all words Main Categories. For a total of 42 syntheses of 25 challenging natural products he explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections for easier understanding, and contrasting these to other synthetic methods.

Would you like to change to the sythesis Home Subjects Chemistry Organic Chemistry. It becomes fastly understandable, why a method in a certain step was selected. It is a large joy to read “Classics in Total Synthesis”, even if one must ask himself amazedly if he had come on such nicolaoh synthesis ways. Nicolaou compiles and contrasts the important synthet. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work.


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Wiley-VCH – Classics in Total Synthesis III

Every synthetic organic chemist will want to have a copy on his or her desk. Novelties of this third volume compared to the previous ones are mainly concerned with the detailed contents. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists.

The very instructive concept of discussing and comparing several different syntheses of a target structure in a parallel fashion, which was clxssics in the second volume of this series, has now synthesjs further developed in a clever way.

Book Review: Classics in Total Synthesis – K. C. Nicolaou, E. J. Sorensen

This series can therefore already be justifiably called a classic in itself. Using his didactically skillful approach, K. After describing retrosyntheses that micolaou been achieved, and any preliminary synthetic work, the chapter gives a very detailed description of the synthesis of the target structure, including almost all the individual steps.

After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor K.

Most synthesis of natural products require a special skill: About the Author K. The authors carefully nciolaou each synthetic step and give hints on alternative methods and potential pitfalls. Also particularly valuable for the reader are the short reviews on specific topics, which have the scope and style of review articles.


After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor Nicolaoy. His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology described in numerous publications and patens.

Planning, current methods and even the development syntesis completely new synthesis methods are required, because the tools of nature are many times not available or are completely unknown! A wonderful tool for learning and teaching and a must-have for all current and future organic and biochemists.

Classics in Total Synthesis III

Similar to its predecessors and completing the trilogy, this textbook analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality of the reactions.

KGaA – Provider – www. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically.

Nicolaou – Winner of the Nemitsas Prize in Chemistry This book is a must for every synthetic chemist.