Sandostatin Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2. Sep 3, Octreotide Acetate (Sandostatin ®) – Intravenous (IV) Dilution. Octreotide (Sandostatin) is the longer acting synthetic analogue of the naturally In patients with cancer and inoperable bowel obstruction octreotide rapidly.
|Published (Last):||25 December 2012|
|PDF File Size:||3.84 Mb|
|ePub File Size:||4.49 Mb|
|Price:||Free* [*Free Regsitration Required]|
Complications following pancreatic surgery For patients undergoing pancreatic surgery, the peri- and post-operative administration of Octreotide reduces the incidence of typical post-operative complications e.
Animal studies have shown excretion of octreotide in breast milk. These patients should be closely monitored during initiation of Octreotide therapy and at each change of dosage.
Packs of 5 and 30 vials containing 1 ml of solution for injection. Sandostatin contains less than 1 mmol 23 mg sodium per dose, i. In most patients, the optimal daily dose will be 0. Lactic acid Mannitol E Sodium hydrogen carbonate Water for injections.
The biochemical characteristic of these tumours is overproduction of vasoactive intestinal peptide VIP. In rare instances, gastrointestinal side effects may resemble acute intestinal obstruction, with progressive abdominal distension, severe epigastric pain, abdominal tenderness and guarding.
This is accompanied by an improvement in associated electrolyte abnormalities, e. It inhibits pathologically increased secretion of growth hormone GH and of peptides and serotonin produced within the GEP endocrine system. Hepatic function should be monitored during octreotide therapy. Use in patients with impaired renal function Impaired renal function did not affect the total exposure AUC to octreotide octreotiide as s.
In most patients, the optimal daily dose will be 0. It is unknown whether octreotide is excreted in human breast milk.
There is a limited amount of data less than pregnancy outcomes from the use of octreotide in pregnant women, and in approximately one third of the cases the pregnancy outcomes are unknown. Diarrhoea, abdominal pain, nausea, constipation, flatulence. No hyperplastic or neoplastic lesions occurred at the s. Pregnancy There is a limited amount of data less than pregnancy outcomes from the use of octreotide in pregnant women, and in approximately one third of the cases the pregnancy outcomes are unknown.
Some retardation of physiological growth was noted in the offspring of rats which was transient and attributable to GH inhibition brought about by excessive pharmacodynamic activity see section 4.
Complications following pancreatic surgery 0. Regarding clinical symptoms, a clear improvement was reported in octreotise out of 32 patients with clinical hyperthyroidism. Complications following pancreatic surgery For patients undergoing pancreatic surgery, the peri- and post-operative administration of Sandostatin reduces the incidence of typical postoperative complications e. This should be repeated as often as necessary until the prescribed duration of treatment is reached.
Symptomatic control and reduction of growth hormone GH and Octreotidd plasma levels in patients with acromegaly who are inadequately controlled by surgery or radiotherapy.
Dosing & Administration
To reduce local discomfort, it is recommended that the solution should be at room temperature before injection. The most commonly reported adverse reactions in clinical trials with octreotide administration were diarrhoea, abdominal pain, nausea, flatulence, headache, cholelithiasis, hyperglycaemia and constipation. To bookmark a medicine you must sign up and log in. Administration of Sandostatin results in most cases in substantial improvement of the necrolytic migratory rash which is characteristic of the condition.
Last updated on eMC: In most patients, octreotide markedly reduces the clinical symptoms of the disease, such as headache, skin and soft tissue swelling, hyperhidrosis, arthralgia, paraesthesia. Octreotide has been found to reduce the intestinal absorption of doeis and to delay that of cimetidine.
Octreotide inhibits secretion of cholecystokinin, resulting in reduced contractility of the gallbladder and an increased risk of sludge and stone formation. The elimination half-life after s. In rats receiving octreotide acetate at daily doses up to 1. Diarrhoea, abdominal pain, nausea, constipation, flatulence.
The only adverse event reported was mild hyperglycaemia. Hypothyroidism, thyroid dysfunction e. For Patients not currently receiving octreotide acetate Begin therapy with Sandostatin Immediate-release Injection.
Sandostatin® LAR Depot Dosing & Administration | HCP
If no relevant reduction doosis GH levels and no improvement in clinical symptoms have been achieved within 3 months of starting treatment with Octreotide therapy should be discontinued. Doses higher than 30 mg are not recommended. Patients on total parenteral nutrition TPN and octreotide should have periodic monitoring of zinc levels.
The most frequent adverse reactions reported during octreotide therapy include gastrointestinal disorders, nervous system disorders, octreeotide disorders, and metabolism and nutritional disorders.
Occurrence of gastrointestinal side-effects may be reduced by avoiding meals around the time of Sandostatin s. Octreotide is a synthetic octapeptide derivative of naturally occurring somatostatin with similar pharmacological effects, but with a considerably prolonged duration of action.
Mixing and Administration Guide Injection should be administered by a health care professional immediately after it is mixed.
Step 9 Prepare injection site with an alcohol wipe Screw safety injection needle onto syringe Gently reshake syringe to a milky uniform suspension Pull protective cover off needle and gently tap syringe to remove and expel any visible bubbles Proceed immediately to Step 10 for administration to the patient, as any delay may dosie in sedimentation.
A limited number of accidental overdoses of octreotide in adults and children have been reported. Sites should be rotated in a systematic manner.