This review presents an analysis of the current data on the structural and functional organization and biological significance of epithelial cell rests of Malassez. Definition: The epithelial cell rests of Malasse are discrete clusters of residual cells from Hertwig’s epithelial root sheath (HERS) that didn’t. The authors performed a PubMed search on the term “epithelial rests” alone or in combination with “Malassez.” Relevant articles were categorized into primary.

Author: Shazuru Mikam
Country: Laos
Language: English (Spanish)
Genre: Finance
Published (Last): 11 November 2004
Pages: 373
PDF File Size: 7.40 Mb
ePub File Size: 15.92 Mb
ISBN: 490-8-53428-983-1
Downloads: 50689
Price: Free* [*Free Regsitration Required]
Uploader: Vukora

Relationship of “epithelial rests of Malassez” to other periodontal structures. Direct stimulation of bone resorption by epidermal growth factor.

Immunohistochemical localization of epithelial rests of Malassez in human periodontal membrane. Epithelial cells, Periodontium, Tooth movement.

In cases of trauma, where the ERM are damaged, leading to necrosis, mediators that promote osteoclasia may not be present in the required concentration, which, as a result, may lead to alveolodental ankylosis. In addition, paracrine signalling through the secretion of mediators of bone resorption would not take place, impacting on the process of bone remodelling around the tooth and leading to the tooth assuming the traits of ankylosis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License. Unlike bone cells, cementoblasts do not have receptors for remodelling mediators, requiring the beginning of a cascade of events that causes the pH to normalize.

Epithelial rests of Malassez: from latent cells to active participation in orthodontic movement

Writing of the article: Sur l’existence damas epitheliaux autour de la racine des dents chez l’homme adulte et a l’etat normal debris epitheliaux paradentaires. Due to the numerous physiological and regenerative functions that ERM perform within the periodontal ligament, the authors suggest that the current nomenclature of epithelial cell “rests” should be replaced by the term epithelial “network” in order to emphasize the central role that these cells play in the homeostasis of the tooth supporting apparatus.


How to cite this article.

Regarding the role of these receptors in osteoclastogenesis, Yi et al 40 demonstrated the inhibition of the signalling pathways affected in this process, which rexts also mediated by the receptor activator of nuclear factor kappa-B ligand RANKL and causes apoptosis through caspase activation.

Bone is a metabolically active specialized form of connective tissue that undergoes continuous remodelling through a tightly regulated interaction between two equivalent and opposing events, specifically, bone resorption of pre-existing bone by osteoclasts, followed by new bone formation by osteoblasts.

According to Maalassez et al, 25 the ERM are related to the repair of cementum due to the release of enamel matrix proteins expressed during tooth development, which is directly associated with epithelial-mesenchymal interactions.

Reeve and Wentz 16 determined the frequency of epithelial rests in patients aged years, classifying different ERM types and locations on the periodontal ligament. Decades later, Legros and Magiot 6 pointed to the epithelial origin of these remaining cells and suggested that they could be associated with the formation of cysts, as dentigerous cysts and odontomas.

Epithelial-mesenchymal interactions induce enamel matrix proteins and proteases in the epithelial cells of the rests of Malassez in vitro. Epithelial-mesenchy-mal transition-derived cells exhibit multi-lineage differentiation potential similar to mesenchymal stem cells. Languages Italiano Edit links. Cementoblasts are involved in the process of remodelling and repair of the root surface.

Furthermore, experiments have established that epithelial cell rests of Malassez contain stem cells that can undergo epithelial-mesenchymal transitions, placing these cells at the centre of periodontal regeneration. Initially, its latent or quiescent role was associated only to the formation of cysts and periapical granulomas.

The results showed that the ERM were present in all 31 specimens analyzed malasssez of agebut the incidence decreased with increasing age. Tuesday 24 May ERM plays a role in cementum repair and regeneration.


However, recent evidence shows that these structures cannot be considered only as cellular debris. Data acquisition, analysis or interpretation: Loe and Waerhaug 17 were the first to epifhelial a compatible function for ERM, having described the spatial distribution of these structures around the tooth root.

Trends in Epithelixl and Met 20 Canalis amelodentineus Fovea enamelea Fovea dentinea. Eur J Oral Sci. Immunohistochemical localization of epithelial rests of Malassez in human periodontal membrane.

These unique structures were, for many years, considered to be quiescent remnants of development, but are now emerging as key role-players in the maintenance of periodontal health and are also implicated in bone resorption through secretion of bone resorption mediators.

In this procedure, epithelial cells associated with ERM modify their distribution and express BMP-2, osteopontin and ameloblastin.

In this procedure, epithelial cells associated with ERM modify their distribution and express BMP-2, osteopontin and ameloblastin.

A total of 23 articles were selected and included in the reference.

epithelial cell rests of Malassez – – Human pathology

When properly executed, the orthodontic movement is able to stimulate the secretory power of these cells, which prevents the recurrence of ankylosis. This result suggests the participation of ERM in the regeneration and repair of cementum. The synthesis of collagen as well as changes in the matrix of the periodontal ligament contribute to the bone remodelling process, which induces orthodontic forces 57epithelixl In subsequent research, Black 8 started to understand them as glandular tissue, 89 findings that have been proven wrong by recent histological studies.